Periaqueductal grey EP3 receptors facilitate spinal nociception in arthritic secondary hypersensitivity

Descending controls on spinal nociceptive processing play a pivotal role in shaping the pain experience following tissue injury. Secondary hypersensitivity develops within undamaged tissue adjacent, and distant to, damaged sites. Spinal neuronal pools innervating regions of secondary hypersensitivity are dominated by descending facilitation that amplifies spinal inputs from un-sensitized peripheral nociceptors. Cyclooxygenase–prostaglandin E2 signaling within the ventrolateral periaqueductal grey (vlPAG) is pro-nociceptive in naïve and acutely inflamed animals but its contributions in more prolonged inflammation and, importantly, secondary hypersensitivity remain unknown. In naïve rats, prostaglandin EP3 receptor (EP3R) antagonism in vlPAG modulated noxious withdrawal reflex (EMG) thresholds to preferential C-, but not A-, nociceptor activation, and raised thermal withdrawal thresholds in awake animals. In rats with inflammatory arthritis, secondary mechanical and thermal hypersensitivity of the hind-paw developed, and this was associated with spinal sensitization to Anociceptor inputs alone. In arthritic rats, blockade of vlPAG EP3R raised EMG thresholds to C-nociceptor activation in the area of secondary hypersensitivity to a degree equivalent to that evoked by the same manipulation in naïve rats

Exact solutions in a scalar-tensor model of dark energy

We consider a model of scalar field with non minimal kinetic and Gauss Bonnet couplings as a source of dark energy. Based on asymptotic limits of the generalized Friedmann equation, we impose restrictions on the kinetic an Gauss-Bonnet couplings. This restrictions considerable simplify the equations, allowing for exact solutions unifying early time matter dominance with transitions to late time quintessence and phantom phases. The stability of the solutions in absence of matter has been studied.Comment: 30 pages, 2 figures, to appear in JCA

Slow-roll Inflation with the Gauss-Bonnet and Chern-Simons Corrections

We study slow-roll inflation with the Gauss-Bonnet and Chern-Simons corrections. We obtain general formulas for the observables: spectral indices, tensor-to-scalar ratio and circular polarization of gravitational waves. The Gauss-Bonnet term violates the consistency relation r = -8n_T. Particularly, blue spectrum n_T > 0 and scale invariant spectrum |8n_T|/r << 1 of tensor modes are possible. These cases require the Gauss-Bonnet coupling function of \xi _{,\phi } \sim 10^8/M_{Pl}. We use examples to show new-inflation-type potential with 10M_{Pl} symmetry breaking scale and potential with flat region in \phi \gtrsim 10M_{Pl} lead to observationally consistent blue and scale invariant spectra, respectively. Hence, these interesting cases can actually be realized. The Chern-Simons term produce circularly polarized tensor modes. We show an observation of these signals supports existence of the Chern-Simons coupling function of \omega _{,\phi } \sim 10^8/M_{Pl}. Thus, with future observations, we can fix or constrain the value of these coupling functions, at the CMB scale.Comment: 21 pages, 5 figure

Scalar cosmological perturbations from inflationary black holes

We study the correction to the scale invariant power spectrum of a scalar field on de Sitter space from small black holes that formed during a pre-inflationary matter dominated era. The formation probability of such black holes is estimated from primordial Gaussian density fluctuations. We determine the correction to the spectrum by first deriving the Keldysh propagator for a massless scalar field on Schwarzschild-de Sitter space. Our results suggest that the effect is strong enough to be tested -- and possibly even ruled out -- by observations.Comment: 41 pages, 11 figures, published versio

Scalar field exact solutions for non-flat FLRW cosmology: A technique from non-linear Schr\"odinger-type formulation

We report a method of solving for canonical scalar field exact solution in a non-flat FLRW universe with barotropic fluid using non-linear Schr\"{o}dinger (NLS)-type formulation in comparison to the method in the standard Friedmann framework. We consider phantom and non-phantom scalar field cases with exponential and power-law accelerating expansion. Analysis on effective equation of state to both cases of expansion is also performed. We speculate and comment on some advantage and disadvantage of using the NLS formulation in solving for the exact solution.Comment: 12 pages, GERG format, Reference added. accepted by Gen. Relativ. and Gra

Generalized thermodynamics and Fokker-Planck equations. Applications to stellar dynamics, two-dimensional turbulence and Jupiter's great red spot

We introduce a new set of generalized Fokker-Planck equations that conserve energy and mass and increase a generalized entropy until a maximum entropy state is reached. The concept of generalized entropies is rigorously justified for continuous Hamiltonian systems undergoing violent relaxation. Tsallis entropies are just a special case of this generalized thermodynamics. Application of these results to stellar dynamics, vortex dynamics and Jupiter's great red spot are proposed. Our prime result is a novel relaxation equation that should offer an easily implementable parametrization of geophysical turbulence. This relaxation equation depends on a single key parameter related to the skewness of the fine-grained vorticity distribution. Usual parametrizations (including a single turbulent viscosity) correspond to the infinite temperature limit of our model. They forget a fundamental systematic drift that acts against diffusion as in Brownian theory. Our generalized Fokker-Planck equations may have applications in other fields of physics such as chemotaxis for bacterial populations. We propose the idea of a classification of generalized entropies in classes of equivalence and provide an aesthetic connexion between topics (vortices, stars, bacteries,...) which were previously disconnected.Comment: Submitted to Phys. Rev.

Cosmological background solutions and cosmological backreactions

The cosmological backreaction proposal, which attempts to account for observations without a primary dark energy source in the stress-energy tensor, has been developed and discussed by means of different approaches. Here, we focus on the concept of cosmological background solutions in order to develop a framework to study different backreaction proposals.Comment: 14 pages, 5 figures; major changes, replaced to match the version published in General Relativity and Gravitatio

Averaging Robertson-Walker Cosmologies

The cosmological backreaction arises when one directly averages the Einstein equations to recover an effective Robertson-Walker cosmology, rather than assuming a background a priori. While usually discussed in the context of dark energy, strictly speaking any cosmological model should be recovered from such a procedure. We apply the Buchert averaging formalism to linear Robertson-Walker universes containing matter, radiation and dark energy and evaluate numerically the discrepancies between the assumed and the averaged behaviour, finding the largest deviations for an Einstein-de Sitter universe, increasing rapidly with Hubble rate to a 0.01% effect for h=0.701. For the LCDM concordance model, the backreaction is of the order of Omega_eff~4x10^-6, with those for dark energy models being within a factor of two or three. The impacts at recombination are of the order of 10^-8 and those in deep radiation domination asymptote to a constant value. While the effective equations of state of the backreactions in Einstein-de Sitter, concordance and quintessence models are generally dust-like, a backreaction with an equation of state w_eff<-1/3 can be found for strongly phantom models.Comment: 18 pages, 11 figures, ReVTeX. Updated to version accepted by JCA

Energy Conditions in f(G)f(G) Modified Gravity with Non-minimal Coupling to Matter

In this paper we study a model of modified gravity with non-minimal coupling between a general function of the Gauss-Bonnet invariant, $f(G)$, and matter Lagrangian from the point of view of the energy conditions. Such model has been introduced in Ref. [21] for description of early inflation and late-time cosmic acceleration. We present the suitable energy conditions for the above mentioned model and then, we use the estimated values of the Hubble, deceleration and jerk parameters to apply the obtained energy conditions to the specific class of modified Gauss-Bonnet models.Comment: 12 pages, no figur, Accepted for publication in Astrophysics and Space Scienc

Volume averaging in the quasispherical Szekeres model

This paper considers the volume averaging in the quasispherical Szekeres model. The volume averaging became of considerable interest after it was shown that the volume acceleration calculated within the averaging framework can be positive even though the local expansion rate is always decelerating. This issue was intensively studied within spherically symmetric models. However, since our Universe is not spherically symmetric similar analysis is needed in non symmetrical models. This papers presents the averaging analysis within the quasispherical Szekeres model which is a non-symmetrical generalisation of the spherically symmetric Lema\^itre--Tolman family of models. Density distribution in the quasispherical Szekeres has a structure of a time-dependent mass dipole superposed on a monopole. This paper shows that when calculating the volume acceleration, $\ddot{a}$, within the Szekeres model, the dipole does not contribute to the final result, hence $\ddot{a}$ only depends on a monopole configuration. Thus, the volume averaging within the Szekeres model leads to literally the same solutions as obtained within the Lema\^itre--Tolman model.Comment: 8 pages; calculation of the spatial Ricci scalar added; accepted for publication in Gen. Rel. Gra